Bibliografie

(eng): The complex (bio)chemical reaction systems, frequently possess fast/slow phenomena, represent both diffculties and challenges for numerical simulation. We develop and test an enhancement of the classical QSSA (quasisteady-state approximation) model reduction method applied to a system of chemical reactions. The novel model reduction method, the so-called delayed quasi-steady-state approximation method, proposed by Vejchodsky (2014) and further developed by Papacek (2021) and Matonoha (2022), is extensively presented on a case study based on Michaelis-Menten enzymatic reaction completed with the substrate transport. Eventually, an innovative approach called the Bohl-Marek method is shown on the same numerical example.